075 Effect of aortic valve replacement on LV remodelling and matrix metalloproteinases and their tissue inhibitors in isolated severe aortic stenosis
نویسندگان
چکیده
منابع مشابه
Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors.
AIMS Aortic valve diseases are characterized by pathological remodelling of valvular tissue but the cellular and molecular effectors involved in these processes are not well known. The role of matrix metalloproteinase (MMP)-2, MMP-9, MMP-3, MMP-7, and tissue inhibitor of matrix metalloproteinase (TIMP)-1 and TIMP-2 are investigated here. METHODS AND RESULTS Histological analysis of pathologic...
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splenomegaly-induced thrombocytopenia is fully described in hematological and surgical literature, but its association with severe aortic stenosis is rare. we present a case of severe aortic valve stenosis with severe splenomegaly-induced thrombocytopenia in which aortic valve replacement was done with a number 23 homograft and splenectomy was performed after the end of cardiopulmonary bypass. ...
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Reports differ regarding the effect of concomitant coronary artery bypass grafting (CABG) in patients who undergo aortic valve replacement (AVR) for aortic stenosis (AS), and no reports have described the effect of aortic valve structure in patients who undergo AVR for AS. A total of 871 patients aged 24 to 94 years (mean 70) whose AVR for AS was their first cardiac operation, with or without f...
متن کاملThe effect of myocardial fibrosis on ventricular remodeling following valve replacement for severe aortic stenosis. A CMR study comparing transcatheter aortic valve implantation and surgical aortic valve replacement
Myocardial fibrosis (MF) that occurs in aortic stenosis (AS) has been shown to be associated with a poor prognostic outcome post surgical aortic valve replacement (SAVR) but not in the high risk patients suitable for Transcatheter aortic valve implantation (TAVI). Using the technique of late-gadolinium enhancement we have shown that MF regresses post-TAVI but not postSAVR, and that ejection fra...
متن کاملThe effects of severe aortic stenosis and high pulmonary artery pressure on aortic valve replacement
Background: Pulmonary hypertension development in pure severe aortic stenosis is a situation that affects mortality and morbidity. Material and Methods: Data from files of 31 patients with systolic pulmonary artery pressure over 50 mm Hg and with pure severe aortic stenosis, and underwent aortic valve replacement in our clinic were examined retrospectively. Results: Preoperative effort capaciti...
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ژورنال
عنوان ژورنال: Heart
سال: 2012
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2012-301877b.75